Maharal (Sotah 22a): Mishna: ... an ascetic woman (isha perusha) and ascetic wounds ... destroy the world. Women are materialistic and therefore asceticism is not relevant for her i.e., to abstain from that which is permitted to her. That is because abstaining from that which is permitted is abstaining from materialism entirely and this is simply not characteristic of women since they are materialistic therefore it is not normal for her to be ascetic. If you do find a woman who is ascetic it is because she wants to be viewed as a righteous woman and thus it is for her benefit – rather than for spiritual purposes. This is similar to “ascetic wounds” It happens to a person who is excessive with his asceticism and he does things which are inappropriate. This is only done is to make an impression on others rather than for spirituality and thus it is not normal. So not only do these two categories fail to build the world they actually are destructive to the well being of the world. That is because all things which are excessive - remove a person from the world. Similarly foolish piety which is also mentioned in this Mishna and a cunning wicked person – because they all act inappropriately. It is very necessary to understand these matters in order that a person knows to do acts of piety with wisdom and common sense.
Torah Shleima (Bereishis 30:16.58):The Yerushalmi Sotah (3:4) states that the “isha perusha” referred to in the mishna is one who sits and insults the words of the Torah which says that Leah said “come to me.” In other words she is proclaiming herself more modest than Leah who directly asked for sexual relations from Yaakov. In fact however she is only doing that in order to insult the words of Torah. This is similar to the explanation of the Pnei Moshe. (In the sefer “Ahl HaYerushalmi” it brings from the Roman Manuscript that the text is not ma’aleves (insults) but ma’aleges (ridicules)... Sotah (22a) explains it means a woman such Yochni bas Retuvi ( who was a witch but she presented herself as a righteous woman). ... However the Tiferes Yisroel (Sotah 3:4) says that an isha perusha is one who truly conducts herself with extreme asceticism. The reason that Chazal say such behavior is destructive is that it is not appropriate for a woman to be ascetic. We see this from another statement of Chazal here that a woman prefers one measure of food (minimal) with sexual excess than 9 measures of food (maximal) with sexual abstinence. Thus condemnation of isha perusha (the ascetic woman) is to understood in the context that asceticism is inherently not appropriate for women. Furthermore the Redal in his comments notes that the Yerushalmi’s comment is to explain the statement here of Rabbi Eliezar that one who teaches his daughter Torah is as if he is teaching her immorality. That is because by means of studying Torah she will become cunning which will enable her to bring support for her immoral behavior from Leah who said to her husband, “come have sex with me.” She will also come to ask directly for sexual intercourse.< [I saw in the Otzer HaChaim that it expresses surprise at the words of this Yerushalmi because at first glance it would seem that there is no connection between the isha perusha (ascetic woman) and the woman arrogantly asking for sexual relations. To answer this problem he answers that he heard that in the library of Paris that there is an edition of the Rambam which has the text “isha perutza” (the wanton woman) instead of our text “isha perusha” (the ascetic woman). That variant text seems to fit the Yerushalmi well. However according to our explanation the text which says “ascetic woman” does in fact make sense. In fact if the variant text is the correct one – there would be no need for any explanations since it would be self-evident that a wanton woman would behave that way.]