Tests in Mice Misled Researchers on 3 Diseases

NYTimes    For decades, mice have been the species of choice in the study of human diseases. But now, researchers report stunning evidence that the mouse model has been totally misleading for at least three major killers — sepsis, burns and trauma. As a result, years and billions of dollars have been wasted following false leads, they say.

The study does not mean that mice are useless models for all human diseases. But, its authors said, it does raise troubling questions about diseases like the ones in the study that involve the immune system, including cancer and heart disease. [...]

The paper, published Monday in the Proceedings of the National Academy of Sciences, helps explain why every one of nearly 150 drugs tested at huge expense in patients with sepsis has failed. The drug tests all were based on studies in mice. And mice, it turns out, have a disease that looks like sepsis in humans, but is very different from the human disease.

Medical experts not associated with the study said that the findings should change the course of research worldwide for a deadly and frustrating disorder. Sepsis afflicts 750,000 patients a year in the United States, kills a quarter to half of them, and costs the nation $17 billion a year. It is the leading cause of death in intensive-care units. [...]

Some researchers, reading the paper now, say they are as astonished as the researchers were when they saw the data.

“When I read the paper, I was stunned by just how bad the mouse data are,” Dr. Fink said. “It’s really amazing – no correlation at all. These data are so persuasive and so robust that I think funding agencies are going to take note.” Until now, he said, “to get funding, you had to propose experiments using the mouse model.”